Plasticizers are the most important ingredient of gun propellant. They have essential role in control of ballistic and mechanical properties of gun propellants. Development of new gun propellants requires study of energetic plasticizers effect. There are lots of researches around the synthesize and application of energetic plasticizers resulting to the production of nitro, nitrato, fluoro nitro, fluoro amino and azido based energetic plasticizers. Using these plasticizers in propellants causes the modification of energy and mechanical strength. In this article, some fundamentals properties of plasticizer, such as glass transition temperature and migration of plasticizers, are explained and then some of the novel plasticizers for gun propellants such as Bu-NENA, DANPE, NF, BDNPA/F, DNDA57 are introduces and their effects on ballistic and other properties of gun propellants are considered.